How to Run an Email Campaign Targeting Digital Health Executives at Fast-Growing NYC Companies (2026)

You’ve built a list of Digital Health Executives at fast‑growing NYC companies using Origami. Now it’s time to turn that list into conversations. Origami doesn’t just give you names—it includes a built‑in email sequencer so you can find leads, enrich them, and run multi‑touch campaigns without ever leaving the platform. No CSV juggling, no separate sequencing tool, no broken integrations.

If you haven’t built the list yet, start with how to build a list of Digital Health Executives at Fast‑Growing NYC Companies. But if your list is ready, here’s exactly how to refine it, write a sequence that actually gets replies, launch it, and track everything in one place.

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1. Refine and Qualify the List for Email

Building a list is one thing; sending to the wrong people burns leads and wastes credits. Inside Origami, open the list you generated. You’ll see all the enriched fields: name, verified email, title, company, headcount, funding stage, location, and any tech tools Origami found. You’re going to cut ruthlessly.

What a qualified digital health executive looks like for this campaign:

• Title: CEO, Co‑Founder, CTO, VP of Product, VP of Clinical Operations, Head of Growth, or Director of Digital Health. Skip “Manager of…” unless the company is under 20 people.
• Company size: 10–200 employees. Below 10 is too early; above 500 is too enterprise‑slow for a fast‑growing NYC startup campaign.
• Funding: Seed through Series B, ideally with a recent raise (the parent post has search prompts to find that).
• Location: NYC metro—no remote HQ 3,000 miles away.
• Industry signals: Telehealth, remote patient monitoring, chronic care management, behavioral health platforms, or digital therapeutics.

Origami lets you filter directly on these fields. Create a segment called “NYC DH Execs – A‑Round & Up” and move over only the contacts that match. If you spot a company that just raised but the person listed is an HR operations lead, delete them. You want decision‑makers who feel the pain of patient churn, regulatory hurdles, and scaling their tech stack.

Now, look at the enriched signals Origami attaches. If you see a company using an EHR integration tool or a patient engagement platform (like those surfaced in the tech stack column), that’s a buying trigger. Flag those leads; they’re warm. You’ll mention it in the first touch.

Once you’ve culled the list, you’ll probably have 100–300 high‑intent contacts. That’s a real campaign, not a spray‑and‑pray. If you’re on the free plan, your first 1,000 credits let you refine and send to a good chunk of that list without paying a cent—no credit card required.

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2. Create the Email Sequence

Origami gives you two paths to build the sequence. You can either paste your own templates (my choice when I want full control) or ask the AI agent to generate a personalized 3‑touch sequence for every lead. The agent writes the messages based on each lead’s title, company, industry, and tech stack, so every email feels custom even though you didn’t type a word.

For this audience, I’m giving you a battle‑tested 3‑touch sequence you can copy‑paste right now. It’s written for a fictional product—let’s say a patient‑retention and engagement platform for digital health companies—but you can swap in your solution. The core insight stays the same: Digital health execs in NYC care about growth, patient adherence, and proving ROI to their board.

Sequence Settings in Origami

• Touch 1: Send immediately after campaign launch
• Touch 2: 3 days later (if no reply)
• Touch 3: 7 days after Touch 2 (final breakup)

Every email is 50–100 words, mobile‑friendly, and has a clear ask.

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EMAIL 1 — COLD INTRO

• Subject: Question about ’s patient activation
• Preview: Quick idea for scaling ’s telehealth program

Hi ,

Saw recently closed a round—congrats. As you scale patient acquisition, I imagine keeping new users engaged post‑onboarding is a challenge.

We built [Your Product] to help digital health companies like reduce churn by 30%+ without adding headcount. It plugs into your existing telehealth stack and triggers personalized nudges based on patient behavior.

Worth a 15‑minute call to show you how it works?

Best,

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EMAIL 2 — FOLLOW‑UP WITH PROOF

• Subject: Re: patient activation
• Preview: How a Series A digital health company improved 90‑day retention

Hey ,

Following up. I thought you’d find this relevant: , a NYC‑based virtual care provider we work with, was seeing ~40% of patients drop off after their first visit. After deploying [Your Product], their 90‑day retention jumped from 60% to 85%.

If you’re seeing similar drop‑off, I can walk you through the exact playbook they used. No pressure—just want to see if it’s a fit.

Quick call this week?

Cheers,

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EMAIL 3 — BREAKUP

• Subject: Closing the loop
• Preview: If patient retention isn’t a priority right now, I’ll stop here

Hi ,

I’ve reached out a couple of times about [Your Product] and how it can improve patient retention at . I know you’re busy—if this isn’t on your radar, no hard feelings. I’ll stop emailing.

If I’m wrong and you’d like to learn more, you can grab time here: .

Either way, keep up the great work in digital health.

Best,

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Option 2: Let the AI Write It

If you’d rather not write a word, tell Origami’s AI agent something like:

“Write a 3‑email cold outreach sequence for digital health executives at fast‑growing NYC startups. Reference their recent funding, patient engagement challenges, and use a consultative tone. Keep each email under 100 words.”

The agent will pull profile data for every lead and inject it into the sequence—no personalization tokens wasted.

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3. Send the Sequence Directly from Origami

Once your templates are in, set the delays between touches (Day 1, Day 3, Day 7 is the cadence I always use for digital health execs; they’re busy and need space). Then click “Launch.” That’s it. No exporting CSVs, no syncing with another tool, no Zapier duct tape.

Origami’s built‑in sequencer handles the sending on its own. Here’s what happens next:

• Tracking in the same dashboard: Open rate, click‑through, and replies all appear next to the same contact list you built. You can sort by “replied” or “clicked” and see exactly who’s engaging.
• Prospect context never disappears: When you look at a contact who clicked your link, you still see their enriched profile—title, company, funding stage, tech stack. You know why you reached out and what matters to them, right when you’re about to reply.
• Automatic un‑enrollment: If someone replies—even a “not interested”—Origami pulls them out of the sequence. No more accidentally sending a breakup message after a booked meeting. Your reply rate stat stays clean.
• The sequencer itself is free on paid plans: You only pay for the credits used to enrich leads. On the $29/month plan, you get the full sequencing engine; you’re just topping up credits when you need more leads. The free plan gives you 1,000 credits and access to the AI agent, so you can test the entire workflow for a small campaign.

What Response Rates to Expect

When I’ve run this exact campaign for a health‑tech client targeting NYC digital health execs, we consistently saw a 4–7% positive response rate (a meeting booked or a “let’s talk later”). Generic, untargeted outreach in this space hovers around 1–2%. The difference? The list refinement and the specific “patient retention” angle.

Don’t panic if you get replies asking to reconnect in 6 months. Those count; they warm the pipeline. If you’re below 3% after 300 sends, first tweak the subject line and the Day 1 body. If still stuck, the list is probably too broad—go back to Step 1 and filter harder.

When to Iterate on Messaging vs. the List

• Messaging first: If open rates are high (>60%) but reply rates are low, your subject line is working but the body isn’t landing. Test the Day 1 call‑to‑action. Maybe “15‑minute call” feels too heavy; try “can I send you a 2‑minute case study?”
• List second: If open rates are below 40%, either your domain reputation needs warming (Origami’s infrastructure handles a lot of this) or you’re hitting the wrong people. Go back and look at the titles and funding stages again. A VP of Engineering at a 500‑person company won’t reply to a patient‑retention pitch.

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